radiosynthesis and biological evaluation of 111in-tris [8-hydroxy-2-methylquinoline] complex as a possible imaging agent
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abstract
introduction: due to the interesting pharmacological properties of radiolabeled metal oxine derivatives such as cell internalization, tumor avidity and antiproteosome activity, 111in-tris[8-hydroxy-2-methylquinoline] (111in-hmq) was developed in this study. methods: 111in-hmq was prepared using 111incl3 and 8-hydroxy-2-methylquinoline (hmq) for 60 min at 100°c (radiochemical purity: >99% itlc, >99% hplc, specific activity: 13-14 gbq/mmol). stability of the complex was checked in final formulation and in the presence of human serum for 48 h. the partition coefficient was calculated for the compound (log p=0.68). results: the biodistribution of the labeled compound in vital organs of wild-type rats was studied using scarification studies and spect up to 24 h. a detailed comparative pharmacokinetic study for 111in cation and 111in-hmq are performed up to 24h. conclusion: the complex is mostly cleaned from the circulation by kidneys and is a compound rapidly washing from the circulation. the biodistribution of the complex in tumor models is on-going.
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Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 19
issue 2 2011
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